What two blood chemistry findings are common in canine hyperadrenocorticism?
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Look for hypercholesterolemia and increased alkaline phosphatase (ALP) in dogs with hyperadrenocorticism (HAC, Cushing disease). HAC is a common canine endocrine disease.
Other clinical pathologic findings include a “stress leukogram” (mature neutrophilia, lymphopenia, monocytosis) and thrombocytosis on CBC analysis and isosthenuria (USG < 1.008 – 1.013) and proteinuria. All these changes result from excess cortisol. Not all cases have all clin path findings; however, approximately 90% dogs with HAC have an increase in ALP.
HAC is uncommon in cats; look for hyperglycemia (80% have concurrent diabetes mellitus), hypercholesterolemia, and increased alanine aminotransferase (ALT). Increased ALP is less common because cats do not have a steroid-induced isoenzyme of ALP, unlike dogs.
