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Kupffer cells are a tissue-associated macrophages that reside in the liver. Kupffer cells are important for mediating the immune response to antigens that pass through the liver from systemic circulation and from the gastrointestinal tract.
Some of the other key tissue-associated resident macrophages are: Osteoclasts – associated with bone Microglial cells – associated with nervous tissue Pulmonary alveolar macrophages of the lungs Sinusoidal lining cells of the spleen
