Which part of a cow’s digestive system has honeycomb appearance to the lining?
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The lining of the reticulum has a honeycomb appearance in cattle.
The proximity of the reticulum to the heart is important because sometimes cows indiscriminately eat pieces of baling wire or nails, which land in the reticulum and then puncture the reticulum and even the heart, causing traumatic reticuloperitonitis (hardware disease).
If you scroll down on the previous link, you can see a picture showing how close everything is anatomically-The esophagus empties food into the reticulum, which is adjacent to the diaphragm and the heart.