Why are most oral antibiotics contraindicated in rabbits and hamsters?
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Rabbits, hamsters and other rodents are very prone to antimicrobials causing enterotoxemia.
Most oral antibiotics disturb their normal gut flora, particularly the beneficial gram-positive bacteria which digest high-fiber food and keep pathogenic Clostridial organisms from over-growing.
Antibiotic-related clostridial enteropathies have been associated with Clostridioides difficile (formerly Clostridium difficile) in hamsters. (remember- DIFFICULTY with ABX = C. difficile in hamsters).
