Which choice best describes how anticoagulant rodenticides cause hypocoagulability?
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Anticoagulant rodenticides inhibit the action of the enzyme vitamin K1 (vit K1) reductase. Without this enzyme, Vit K1 epoxide (inactive form) cannot be recycled into vit K1 (active form).
Vit K1 is necessary for the formation of clotting factors II, VII, IX and X (vit K-dependent clotting factors).
Factor VII (part of extrinsic pathway) has the shortest half-life. Thus, prothombin time (PT) will be prolonged before activated partial thromboplastin time (PTT).
