Which drug can reverse the effects of xylazine (an alpha2-adrenergic agonist)?
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Yohimbine is the reversal agent for xylazine (an alpha-2 adrenergic agonist) commonly used as a sedative in large animals. Yohimbine is also an antidote for amitraz (an insecticide) toxicosis.
Remember that cattle are extremely sensitive to xylazine, the cow dose is about 1/10 the dose in horses.
Pralidoxime is used to treat organophosphate toxicity, along with a sedative for seizures (e.g., diazepam) and atropine.
Flumazenil is the reversal agent for benzodiazepines and naloxone is an opioid reversal agent.
